Genetic testing is currently piloted in Singapore for individuals with kidney diseases suspected to be due to genetic causes. Genetic testing can also be offered to healthy individuals who may be at risk of developing kidney diseases in the future (e.g. for those considered at risk based on family history). On average, up to …
Who is eligible for RAPIDS project? This project invites volunteers who are adults, adolescents and children with glomerular diseases suspected to be genetic in nature. There is no age limit. Subjects will have to provide written consent to participate in this research project. Where can you get tested? Genetic testing for glomerular diseases is …
How can you get genetic testing for glomerular diseases done in Singapore? Read More »
Why do family members need genetic testing? If you have a family member who has undergone genetic testing, you may be asked by your family member’s doctor to undergo a genetic test yourself. There are several possible reasons why this genetic test is recommended to you: (not all may apply to you) To provide …
What is genetic testing? Genes are made up of DNA. They contain instructions for our body functions. Genetic testing is an evaluation of your genes and it can identify DNA changes that may cause kidney diseases. Understanding genes Genes are lined up on the DNA strands. Each gene is made up of several coding …
Coenzyme Q10 deficiency is one of the few rare genetic kidney disease that has a specific treatment. Genes involved in this condition include PDSS1, PDSS2, COQ2, COQ4, COQ5, COQ6, COQ7, COQ8A, COQ8B and COQ9. Two abnormal gene copies need to be present to cause disease. The kidney disease associated with this condition has varying …
Alport syndrome is caused by changes in genes that make different types of collagen (COL4A3, COL4A4, COL4A5). These collagens are involved in the functions of many organs, namely kidneys, inner ears and eyes. It is one of the commonest genetic cause of glomerular disease among adults and children in Asian countries. There are three …
FSGS is a term used to describe the appearance seen on a kidney biopsy. It suggests areas of “scarring” within some of the glomeruli. There are many causes of FSGS. These include: Immune causes: The exact immune mechanism is still unknown. Genetic causes: About 50-60 genes have been identified to cause FSGS. Other causes: …
What are kidney diseases? Some kidney diseases can be due to genetic causes. Depending on the type of kidney disease and specific risks factors, the likelihood of genetic causes in a kidney patient can range from 10-70%. Glomerular diseases are a group of kidney conditions which can have genetic causes. What are glomerular …